Open Access Highly Accessed Open Badges Review article

The omics in migraine

Luana Lionetto1*, Giovanna Gentile2, Elisa Bellei3, Matilde Capi1, Donata Sabato1, Francesco Marsibilio4, Maurizio Simmaco12, Luigi Alberto Pini5 and Paolo Martelletti46

Author Affiliations

1 Sant’Andrea Hospital, Advanced Molecular Diagnostics Unit, Via di Grottarossa 1035 – 1039, Rome 00189, Italy

2 NESMOS Department, Sapienza University of Rome, Rome, Italy

3 Department of Diagnostic Medicine, Clinic and Public Health, University of Modena and Reggio Emilia, Modena, Italy

4 Regional Referral Headache Centre, Sant’Andrea Hospital, Rome, Italy

5 Inter-Department Headache and Drug Abuse Centre, University of Modena and Reggio Emilia, Modena, Italy

6 Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy

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The Journal of Headache and Pain 2013, 14:55  doi:10.1186/1129-2377-14-55

Published: 1 July 2013


The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study model, due to its multifactorial nature. In this review, the plainly research data featuring in this complex network are reported and analyzed, as single or multiple factor in pathophysiology of migraine. The future of migraine biomolecular research shall be focused on networking among these different and hierarchical disciplines. We have to look for its Ariadne’s tread, in order to see the whole painting of migraine molecular biology.

Genomics; Proteomics; Metabolomics; Migraine